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Monday, August 3, 2020 | History

1 edition of Interferon alfa-2a in cancer therapy found in the catalog.

Interferon alfa-2a in cancer therapy

Interferon alfa-2a in cancer therapy

proceedings of an official satellite symposium to the 14th International UICC Cancer Congress, Budapest, Hungary, 22 August 1986

  • 273 Want to read
  • 28 Currently reading

Published by A.R. Liss in New York .
Written in English

    Subjects:
  • Interferon -- Congresses.,
  • Tumors -- Treatment -- Congresses.

  • Edition Notes

    Includes bibliographies.

    Statementchairman, K. Sikora ; co-chairman, M. Benczur.
    SeriesInternational journal of cancer -- 1., International journal of cancer -- no. 1.
    ContributionsBenczur, M., Sikora, Karol., International Union against Cancer., International Cancer Congress (14th : 1986 : Budapest, Hungary)
    The Physical Object
    Pagination45 p. :
    Number of Pages45
    ID Numbers
    Open LibraryOL17642955M

    Severe bowel problems have happened within 12 weeks of treatment with alpha interferons like peginterferon alfa-2a. Sometimes, this could be deadly. Sometimes, this could be deadly. Call your /   Escudier B, Pluzanska A, Koralewski P, et al.: Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial. Lancet Author: PDQ Adult Treatment Editorial Board.

      In , the Scottish melanoma group initiated a randomized trial, comparing observation alone with 6 months' therapy with low dose interferon α (given subcutaneously 3 MU day–1, thrice Cited by: SOURCES: Cancer Research UK: "Interferon (Intron A)," "Side Effects of Interferon (Intron A)." Clinical and Experimental Hepatology: "Recommendations for the treatment of hepatitis C in

    PEG-interferon alfa-2a A covalent conjugate of recombinant interferon alfa, subtype 2a, and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent. The biological activity of this agent is derived from its interferon . Cancer Research UK: "Interferon (Intron A)," "Side Effects of Interferon (Intron A)." Clinical and Experimental Hepatology: "Recommendations for the treatment of hepatitis C in ".


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Interferon alfa-2a in cancer therapy Download PDF EPUB FB2

Alpha interferon is a cytokine produced by the innate immune system in response to environmental exposures including viral infections. Alpha interferon in various formulations has been developed as therapy of several forms of cancer and viral infections, but its major use has been as therapy of chronic hepatitis C.

Alpha interferon therapy. To evaluate the toxicity, safety and tolerability of Pegylated Interferon Alfa-2a therapy in the study populations. To measure the impact of Pegylated Interferon Alfa-2a on key biomarkers of the. Clinical trials are research studies that involve people.

The clinical trials on this list are studying Recombinant Interferon Alfa-2a. All trials on the list are supported by NCI.

NCI’s basic information. When combined with prior observations or with other effective modalities for cancer treatment, modulation of the interferon system could contribute to further reductions in cancer Cited by: While referencing advances in traditional therapies and treatments such as chemotherapy, this book also highlights advances in biotherapy including research using Interferon and Super Interferon, HecI based and liposome based therapy, gene therapy, and p53 based cancer therapy.

ET causes people to produce too many blood cells called platelets and PV causes too many platelets and red blood cells to be made. The purpose of this study is to look at the effectiveness of giving participants who have been diagnosed with ET or PV one of two different study regimens over time.

The study regimens are either “PEGASYS” (or pegylated interferon alfa-2a [PEG interferon alfa-2a. Cytokine therapy to activate the immune system of cancer patients has been an important treatment modality and continues to be a key contributor to current clinical cancer research.

Interferon alpha (IFNα) is approved for adjuvant treatment Cited by: Interferon alfa-2a should be used with extreme caution in patients who reported a history of depression.

If a patient develops clinically significant depression, interruption of therapy with interferon alfa-2a should be considered. Depression has been reported to have sometimes continued after decreases in dosage or discontinuation of therapy.

Nonetheless, combination therapy of oral cis-retinoic acid and subcutaneous interferon alfa-2a may represent an effective second-line treatment for recurrent AS. We intend to keep the current dosage for a total period of 2 years before lowering the dose of cis -retinoic acid in small decrements, while maintaining the present interferon Cited by: Interferons and interleukins for cancer treatment.

In immunotherapy treatment, oncologists use antibodies, vaccines, immunotoxins, bacteria, immune cells, and cytokines to stimulate the immune system and to reduce the risk of cancer recurring. Currently, just two cytokines (IFNα and IL-2) are employed by doctors to treat cancer.

Kimmick, G. et al. Subcutaneously administered recombinant human interleukin-2 and interferon alfa-2a for advanced breast cancer: a phase II study of the Cancer and Leukemia Group B Cited by: Cancer Research UK: "Interferon (Intron A)," "Side Effects of Interferon (Intron A)." Clinical and Experimental Hepatology: "Recommendations for the treatment of hepatitis C in "Author: Stephanie Watson.

Interferon is a popular first line therapy for metastatic RCC and many conservative oncologists prefer Interferon to IL-2 based therapy, perhaps because of its milder side effects.

This includes doctors at some of the very best cancer hospitals. Minasian LM, Motzer RJ, Gluck L, et al. Interferon alfa-2a in advanced renal cell carcinoma: treatment results and survival in patients with long-term follow-up, J.

Clin. Oncol., 11 () – Cited by: 8. Recombinant interferon alfa-2b is also used to treat some infections caused by viruses, such as the hepatitis C virus. It is being studied in the treatment of other types of cancer and other conditions.

Recombinant interferon alfa-2b is a form of interferon alfa. Interferon alfa-2a is in the FDA pregnancy category C. This means that it is not known whether interferon alfa-2a will be harmful to an unborn baby.

Do not use this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether interferon. What are some things I need to know or do while I take Interferon Alfa-2a.

For all uses of interferon alfa-2a: Tell all of your health care providers that you take interferon alfa-2a. This includes your. The MPD-RC study evaluated the activity of pegylated interferon alfa-2a in patients who were previously refractory to, or intolerant of, hydroxyurea and showed an overall response at 12 Author: John Mascarenhas.

Interferon alfa-2b injection is used to treat hepatitis B and C, lymphoma (lymph node cancer), malignant melanoma (skin cancer), genital warts, hairy cell leukemia (blood cell cancer), and Kaposi sarcoma.

There was one treatment-related death in each group. Treatment was discontinued because of side effects (mainly influenza-like, gastrointestinal, or neurologic symptoms) in 35 patients given interferon alfa-2a (16 percent). The cost of interferon treatment was times that of the conventional by:. Interferon alpha is a biological therapy that may be used to treat kidney cancer, melanoma, carcinoid tumours and some types of lymphoma and leukaemia.

During treatment, you will see a cancer doctor and a cancer .M. Ferrantini, F. BelardelliGene therapy of cancer with interferon: lessons from tumor models and perspectives for clinical applications Semin. Cancer Biol., 10 (), pp. Cited by:   We conducted a phase II study of pegylated interferon alfa-2a (PEG-IFN-α-2a) in patients with essential thrombocythemia (ET) and polycythemia vera (PV).Seventy-nine patients (40 Cited by: